HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking by Sonoda J, Koriyama C, Yamamoto S, Kozako T, Li HC, Lema C, Yashiki S, Fujiyoshi T, Yoshinaga M, Nagata Y, Akiba S, Takezaki T, Yamada K, Sonoda S.
Human T-cell lymphotropic virus type 1 (HTLV-1) is causatively
associated with adult T-cell leukemia (ATL) and HTLV-1-associated
myelopathy/tropical spastic paraparesis (HAM/TSP). Since a high
level of HTLV-1 provirus load in circulating lymphocytes is thought
to be a risk for ATL and HAM/TSP, diminution of HTLV-1 provirus
load in the circulation may prevent these intractable diseases. Our
previous study (Jpn J Cancer Res 2000; 91: 34-40) demonstrated that
green tea polyphenols inhibit in vitro growth of ATL cells, as well
as HTLV-1-infected T-cells. The present study aimed to investigate
the in vivo effect of green tea polyphenols on HTLV-1 provirus load
in peripheral blood lymphocytes on HTLV-1 carriers. We recruited 83
asymptomatic HTLV-1 carriers to examine HTLV-1 provirus DNA with or
without administration of capsulated green tea extract powder.
Thirty-seven subjects were followed up for 5 months by measuring
HTLV-1 provirus load after daily intake of 9 capsules of green tea
extract powder per day (equivalent to 10 cups of regular green
tea), and 46 subjects lived ad libitum without intake of any green
tea capsule. The real-time PCR quantification of HTLV-1 DNA
revealed a wide range of variation of HTLV-1 provirus load among
asymptomatic HTLV-1 carriers (0.2-200.2 copies of HTLV-1 provirus
load per 1000 peripheral blood lymphocytes). Daily intake of the
capsulated green tea for 5 months significantly diminished the
HTLV-1 provirus load as compared with the controls (P = 0.031).
These results suggest that green tea drinking suppresses
proliferation of HTLV-1-infected lymphocytes in vivo.
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